Vědecká práce
Václav Hampl
Zabývám se regulací plicní a fetoplacentární cirkulace, zejména při nedostatku kyslíku. Zajímá mě také podíl endotelu na této regulaci, zejména oxidu dusnatého (NO).

Odborné publikace (odkaz na ResearcherID; povšimněte si možnosti přístupu ke kompletním textům u většiny recentních).  
Citační analýza (WoS  24. 2. 2017):
Analyzed publications (jen dokumenty typu "ARTICLE", "REVIEW" a "PROCEEDINGS" - ne abstrakta apod.): 50
Sum of the times cited: 2814
Without self-citations: 2688 (autocitations are 4.5 % of citations)
Average citations per publication: 56.3
Without self-citations: 53.8
h-index: 24
h-index (Hirschův index) je počet publikací h, které jsou citovány alespoň h-krát. h-index 24 tedy znamená, že 24 z mých prací je každá citována alespoň 24x.
Most cited publications:
Archer S.L., Huang J.M.-C., Hampl V., Nelson D.P., Shultz P.J., Weir E.K.: Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America 91: 7583-7587, 1994.
Cited 576x
Archer S.L., Souil E., Dinh-Xuan A.T., Schremmer B., Mercier J.-C., El Yaagoubi A., Nguyen-Huu L., Reeve H.L., Hampl V.: Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and 2.1 in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes. Journal of Clinical Investigation 101: 2319-2330, 1998.
Cited 281x
Archer S.L., Huang J.M.C., Reeve H.L., Hampl V., Tolarová S., Michelakis E., Weir E.K.: Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia. Circulation Research 78: 431-442, 1996.
Cited 268x
Michelakis E.D., Hampl V., Nsair A., Wu X., Harry G., Haromy A., Gurtu R., Archer S.: Diversity in mitochondrial function explains differences in vascular oxygen sensing. Circulation Research 91: 1307-1315, 2002.
Cited 197x
Hampl V., Herget J.: Role of nitric oxide in the pathogenesis of chronic pulmonary hypertension. Physiological Reviews 80: 1337-1372, 2000.
Cited 170x
Weir E.K., Reeve H.L., Huang J.M.C., Michelakis E., Nelson D.P., Hampl V., Archer S.L.: Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction. Circulation 94: 2216-2220, 1996.
Cited 145x
Isaacson T.C., Hampl V., Weir E.K., Nelson D.P., Archer S.L.: Increased endothelium-derived nitric oxide in hypertensive pulmonary circulation of chronically hypoxic rats. Journal of Applied Physiology 76: 933-940, 1994.
Cited 127x  
Hampl V., Archer S.L., Nelson D.P., Weir E.K.: Chronic EDRF inhibition and hypoxia: effects on pulmonary circulation and systemic blood pressure. Journal of Applied Physiology 75: 1748-1757, 1993.
Cited 107x
Hampl V., Cornfield D.N., Cowan N.J., Archer S.L.: Hypoxia potentiates nitric oxide synthesis and transiently increases cytosolic calcium levels in pulmonary artery endothelial cells. European Respiratory Journal 8: 515-522, 1995.
Cited 95x
Archer S.L., London B., Hampl V., Wu X.C., Nsair A., Puttagunta L., Hashimoto K., Waite R.E., Michelakis E.D.: Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5. FASEB Journal 15: 1801- (DOI: 10.1096/fj.00-0649fje), 2001.
Cited 87x
Dalších 15:
Archer S.L., Hampl V.: NG-monomethyl-L-arginine causes nitric oxide synthesis in isolated arterial rings: trouble in paradise. Biochemical and Biophysical Research Communications 188: 590-596, 1992.
Cited 80x
Dillon W.C., Hampl V., Shultz P.J., Rubins J.B., Archer S.L.: Origins of breath nitric oxide in humans. Chest 110: 930-938, 1996.
Cited 64x
Hampl V., Herget J.: Perinatal hypoxia increases hypoxic pulmonary vasoconstriction in adult-rats recovering from chronic exposure to hypoxia. American Review Of Respiratory Diseases 142: 619-624, 1990.
Cited 62x
Hampl V., Bíbová J., Straňák Z., Wu X.C., Michelakis E.D., Hashimoto K., Archer S.L.: Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition. American Journal Of Physiology-Heart and Circulatory Physiology 283: H2440-H2449, 2002.
Cited 59x
Hampl V., Tristani-Firouzi M., Hutsell T.C., Archer S.L.: Nebulized nitric oxide nucleophile adduct reduces chronic pulmonary hypertension. Cardiovascular Research 31: 55-62, 1996.
Cited 46x
Archer S.L., Hampl V., Nelson D.P., Sidney E., Peterson D.A., Weir E.K.: Dithionite increases radical formation and decreases vasoconstriction in the lung - evidence that dithionite does not mimic alveolar hypoxia. Circulation Research 77: 174-181, 1995.
Cited 35x
Lachmanová V., Hniličková O., Povýšilová V., Hampl V., Herget J.: N-acetylcysteine inhibits hypoxic pulmonary hypertension most effectively in the initial phase of chronic hypoxia. Life Sciences 77: 175-182, 2005.
Cited 34x
Hampl V., Bíbová J., Povýšilová V., Herget J.: Dehydroepiandrosterone sulphate reduces chronic hypoxic pulmonary hypertension in rats. European Respiratory Journal 21: 862-865, 2003.
Cited 33x
Hampl V., Bíbová J., Baňasová A., Uhlík J., Miková D., Hniličková O., Lachmanová V., Herget J.: Pulmonary vascular iNOS induction participates in the onset of chronic hypoxic pulmonary hypertension. American Journal Of Physiology-Lung Cellular and Molecular Physiology 290: L11-L20, 2006.
Cited 27x
Hampl V., Huang J.M., Weir E.K., Archer S.L.: Activation of the cGMP-dependent protein-kinase mimics the stimulatory effect of nitric oxide and cGMP on calcium-gated potassium channels. Physiological Research 44: 39-44, 1995.
Cited 27x
Ošťádalová I., Vobecký M., Chvojková Z., Miková D., Hampl V., Wilhelm J., Ošťádal B.: Selenium protects the immature rat heart against ischemia/reperfusion injury. Molecular and Cellular Biochemistry 300: 259-267, 2007
Cited 26x
Bělohlávková S., Šimák J., Kokešová A., Hniličková O., Hampl V.: Fenfluramine-induced pulmonary vasoconstriction: role of serotonin receptors and potassium channels. Journal of Applied Physiology 91: 755-761, 2001.
Cited 26x
Vajner L., Vytášek R., Lachmanová V., Uhlík J., Konrádová V., Novotná J., Hampl V., Herget J.: Acute and chronic hypoxia as well as 7-day recovery from chronic hypoxia affects the distribution of pulmonary mast cells and their MMP-13 expression in rats. International Journal of Experimental Pathology 87: 383-391, 2006.
Cited 24x
Herget J., Novotná J., Bíbová J., Povýšilová V., Vaňková M., Hampl V.: Metalloproteinase inhibition by Batimastat attenuates pulmonary hypertension in chronically hypoxic rats. American Journal Of Physiology-Lung Cellular and Molecular Physiology 285: L199-L208, 2003.
Cited 24x
Baňasová A., Maxová H., Hampl V., Vízek M., Povýšilová V., Novotná J., Vajnerová O., Hniličková O., Herget J.: Prevention of mast cell degranulation by disodium cromoglycate attenuates the development of hypoxic pulmonary hypertension in rats exposed to chronic hypoxia. Respiration 76: 102-107, 2008.
Cited 23x

ResearcherID
Kvalifikační spisy:
Dizertace (1989). Pro www jsem připravil 2 části teoretického úvodu: Akutní hypoxická plicní vazokonstrikce a Chronická hypoxická plicní hypertenze (obojí s pár drobnými pozdějšími úpravami). Experimentální část byla uveřejněna v 5 samostatných publikacích: Hampl & Herget 1990, Herget & Hampl 1990, Hampl & Herget 1991, Falus et al 1991 a Hampl & Herget 1992.
Habilitace (1997)
DrSc (2001)
Profesura (2001)


Doktorandi, které vedu
 
Naše laboratoř NO


Zpět na domácí stránku V.H.